Histological examination:
showed a uterine carcino-sarcoma spreading to external orifice. Metastasis was confirmed in the omentum, iliac lymph nodes on the left side and the right ovary. Staged at T3N1M0.
Over the next 5 months, she received 4 courses of chemotherapy (Paclitaxel, Carboplatin) and 2 courses of radiotherapy.
At her 3 month, post therapy staging PET / CT she was found to have metastases to the right lung, liver, and mesenteric tissue. She was then switched to second line therapy. She received 2 further courses with Docetaxel and Gemcitabine. A further staging CT showed metastasis to the liver, peritoneum, abdominal lymph nodes, lungs, and bones. She received chemotherapy with Pazopanib.
Immunohistochemical examination of ovaries confirmed highly aggressive endometrioid carcinoma of the right ovary.
Diagnosis: Uterus carcinosarcoma, endometrioid carcinoma of the right ovary
The patient did not continue further therapy due to her clinical and performance status, developed progressive malignant ascites requiring laparocentesis. She passed away 6 months from initial presentation and no post-mortem was performed.