Aspergillus Endocarditis in a prosthetic Valve following COVID-19 Infection


fungal endocarditis
infective endocarditis
post COVID fungal infection

How to Cite

vegiraju, S. M. (2023). Aspergillus Endocarditis in a prosthetic Valve following COVID-19 Infection: Case Report. The Physician, 8(1), 1-4.


Endocarditis of a prosthetic valve is a known but rare occurrence. Fungal endocarditis is extremely rare. However, in the COVID-19 pandemic, there has been increasing recognition of fungal or yeast-related infections, often due to the combination of immune paresis, concurrent use of corticosteroids or underlying chronic conditions such as diabetes or neoplasms.

We present a patient with fulminating, invasive aspergillosis of a prosthetic aortic valve who presented with catastrophic cardiovascular failure needing intensive care management. Early recognition and prompt therapy is the cornerstone of success in such presentations with high mortality.


Najafi N, Moslemi A, Ghafari R, et al. Post-COVID-19 fatal Aspergillus endocarditis: A case report. Journal of Clinical Laboratory Analysis 2023;37:e24816. doi:10.1002/jcla.24816

Jalalian R, Shokohi T, Mirzakhani R, et al. Fatal Prosthetic Valve Endocarditis Due to Aspergillus flavus in a Diabetic Patient. IDR 2020;Volume 13:2245–50. doi:10.2147/IDR.S258637

Born T, Aruanno M, Kampouri E, et al. Aspergillus tubingensis Endocarditis: A Case Report and Review of the Literature. Mycopathologia 2022;187:249–58. doi:10.1007/s11046-022-00621-0

Meshaal MS, Labib D, Said K, et al. Aspergillus endocarditis: Diagnostic criteria and predictors of outcome, A retrospective cohort study. PLoS One 2018;13:e0201459. doi:10.1371/journal.pone.0201459

Zhang H, Zhang Y, Wu J, et al. Risks and features of secondary infections in severe and critical ill COVID-19 patients. Emerg Microbes Infect 2020;9:1958–64. doi:10.1080/22221751.2020.1812437

Musuuza JS, Watson L, Parmasad V, et al. Prevalence and outcomes of co-infection and superinfection with SARS-CoV-2 and other pathogens: A systematic review and meta-analysis. PLoS One 2021;16:e0251170. doi:10.1371/journal.pone.0251170

Kundu R, Singla N. COVID-19 and Plethora of Fungal Infections. Curr Fungal Infect Rep 2022;16:47–54. doi:10.1007/s12281-022-00432-2

Kalokhe AS, Rouphael N, El Chami MF, et al. Aspergillus endocarditis: a review of the literature. International Journal of Infectious Diseases 2010;14:e1040–7. doi:10.1016/j.ijid.2010.08.005

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