Combination Correctors and Potentiators for Cystic Fibrosis
green picture of coronavirus


cystic fibrosis
Phe508del mitation
combination correctors

How to Cite

Basta, K., & John, C. (2019). Combination Correctors and Potentiators for Cystic Fibrosis: A Systematic Review and Meta-analysis . The Physician, 6(1), c7.


The most common cause of cystic fibrosis (CF) is the Phe508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, resulting in CFTR’s reduced trafficking, targeted by correctors, and reduced functioning, targeted by potentiators. For the majority of CF patients, the combination correctors and potentiators (CCPs) lumacaftor/ivacaftor and tezacaftor/ivacaftor, are the only treatments licensed to target the disease origin.


Peer reviewed by Sunil Daga PhD MRCP and Subarna Chakravorty PhD FRCPath for BAPIO Annual Conference, London 2019

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2019 Array