The coronavirus (COVID-19) pandemic has serious health implications. The potential risk to pregnant women and neonates must be explored. Controversy exists regarding whether Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can be transmitted vertically via antenatal or intrapartum transmission from an infected mother to her child. Emerging case reports and cohort studies suggest that vertical transmission is likely. However, the data is limited and contradictory, making it difficult to draw definitive conclusions. The continued collection and analysis of data on pregnant women and neonates is necessary.
Henley, J. More than a million confirmed cases of Covid-19 globally, <https://www.theguardian.com/world/2020/apr/02/top-european-teaching-hospitals-running-out-of-coronavirus-drugs> (2020).
RCOG. Guidance for healthcare professionals on coronavirus (COVID-19) infection in pregnancy, published by the RCOG, Royal College of Midwives, Royal College of Paediatrics and Child Health, Public Health England and Health Protection Scotland., <https://www.rcog.org.uk/globalassets/documents/guidelines/2020-04-03-coronavirus-covid-19-infection-in-pregnancy.pdf> (2020).
Guan, W.-j. et al. Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine, doi:10.1056/NEJMoa2002032 (2020).
Zhu, N. et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med 382, 727-733, doi:10.1056/NEJMoa2001017 (2020).
Chen, H. et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The Lancet 395, 809-815, doi:10.1016/S0140-6736(20)30360-3 (2020).
Zeng, L. et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatrics, doi:10.1001/jamapediatrics.2020.0878 (2020).
Dong, L. et al. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA, doi:10.1001/jama.2020.4621 (2020).
Palmeira, P., Quinello, C., Silveira-Lessa, A. L., Zago, C. A. & Carneiro-Sampaio, M. IgG placental transfer in healthy and pathological pregnancies. Clin Dev Immunol 2012, 985646, doi:10.1155/2012/985646 (2012).
Bouthry, E. et al. Rubella and pregnancy: diagnosis, management and outcomes. Prenat Diagn 34, 1246-1253, doi:10.1002/pd.4467 (2014).
Gottfredsson, M. [The Spanish flu in Iceland 1918. Lessons in medicine and history]. Laeknabladid 94, 737-745 (2008).
Wong, S. F. et al. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet Gynecol 191, 292-297, doi:10.1016/j.ajog.2003.11.019 (2004).
Who. (World Health Organization, 2003).
Public Health England - Guidance on shielding and protecting people defined on medical grounds as extremely vulnerable from COVID-19, <https://www.gov.uk/government/publications/guidance-on-shielding-and-protecting-extremely-vulnerable-persons-from-covid-19/guidance-on-shielding-and-protecting-extremely-vulnerable-persons-from-covid-19> (2020).
Zhang, J. P., Wang, Y. H., Chen, L. N., Zhang, R. & Xie, Y. F. [Clinical analysis of pregnancy in second and third trimesters complicated severe acute respiratory syndrome]. Zhonghua Fu Chan Ke Za Zhi 38, 516-520 (2003).
Sinha, I. P. et al. COVID-19 infection in children. The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(20)30152-1.
Dong, Y. et al. Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China. Pediatrics, e20200702, doi:10.1542/peds.2020-0702 (2020).
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