On April 26, 2020, clinicians in the United Kingdom (UK) recognized increased reports of previously healthy children presenting with a severe inflammatory syndrome with Kawasaki disease-like features. The cases occurred in children testing positive for current or recent infection by SARS-CoV-2, the novel coronavirus that causes COVID-19, based on reverse-transcriptase polymerase chain reaction (RT-PCR) or serologic assay, or who had an epidemiologic link to a COVID-19 case. Patients presented with persistent fever and a constellation of symptoms including hypotension, multiorgan (e.g., cardiac, gastrointestinal, renal, hematologic, dermatologic and neurologic) involvement, and elevated inflammatory markers.2 Respiratory symptoms were not present in all cases. The Centers for Disease Control and Prevention (CDC) has provided background information on several cases, and a case definition for this syndrome. There is an enhanced alert for all health providers to be aware of this new diagnosis and report cases that they encounter urgently. This quick review provides an overview of the evidence so far and will be useful for those caring for children in the pandemic and beyond.
WHO Director-General's opening remarks at the media briefing on COVID-19—11 March 2020". World Health Organization. 11 March 2020. Retrieved on 23rd May 2020
European Centre for Disease Prevention and Control. Paediatric inflammatory multisystem syndrome and SARS-CoV-2 infection in children – 14 May 2020. ECDC: Stockholm; 2020.
Castagnoli R, Votto M, Licari A, Brambilla I, Bruno R, Perlini S, et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review. JAMA pediatrics. 2020
Parri N, Lenge M, Buonsenso D. Children with Covid-19 in Pediatric Emergency Departments in Italy. The New England journal of medicine. 2020.
Riphagen S et al, Hyperinflammatory shock in children during COVID-19 pandemic. Lancet Published: May 07, 2020.
RCPCH https://www.rcpch.ac.uk/sites/default/files/2020-05/COVID-19-Paediatric-multisystem-%20inflammatory%20syndrome-20200501.pdf Accessed 23rd may, 2020.
Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020. MMWR Morbidity and mortality weekly report 2020;69(14):422-6.
Paediatric Multisystem Inflammatory Syndrome, Don't Forget the Bubbles, 2020. Available at: http://doi.org/10.31440/DFTB.25760.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2020 Array