BAME children are most at risk of developing Multisystem Inflammatory Syndrome-Temporally Associated with COVID-19
picture of 4 children




Multi-system Inflammatory Syndrome - Temporally Associated with SARS-CoV-2 infection

How to Cite

Rao, S., & Sandhu, B. (2020). BAME children are most at risk of developing Multisystem Inflammatory Syndrome-Temporally Associated with COVID-19. The Physician, 6(1). (Original work published May 24, 2020)


Key points:

In the current climate, it is essential that all professionals dealing with children are aware of Multisystem Inflammatory Syndrome. The children may present in primary care, emergency department or to Paediatrics with a variety of symptoms. Majority of the children have mild or moderate symptoms, though the small minority may deteriorate quickly.


  1. Early recognition and diagnosis of Multisystem Inflammatory Syndrome are essential to ensure early treatment and reduce morbidity and the risk of long-term complications particularly coronary artery aneurysms.
  2. Children from BAME backgrounds appear to be more commonly affected. The reasons for this are likely to be multifactorial including socio-economic factors3, health care seeking behaviour, but possible genetic influences on susceptibility15 also need researching. Preliminary signals must be explored urgently16. Data collection on ethnicity should be included in all future studies.
  3. Children with mild to moderate disease require only supportive care. For more severe cases particularly if they have comorbidities and or are from  BAME group, the involvement of specialists and referral to Paediatric intensive care should be considered early.


WHO Director-General's opening remarks at the media briefing on COVID-19—11 March 2020". World Health Organization. 11 March 2020.

European Centre for Disease Prevention and Control. Paediatric inflammatory multisystem syndrome and SARS-CoV-2 infection in children – 14 May 2020. ECDC: Stockholm; 2020.

Harman, K., A. Verma, J. Cook, T. Radia, M. Zuckerman, A. Deep, A. Dhawan and A. Gupta (2020). "Ethnicity and COVID-19 in children with comorbidities." Lancet Child Adolesc Health. Published on line May 28th 2020.

Castagnoli R, Votto M, Licari A et al. Acute Respiratory Syndrome Coronavirus 2 (SAR. S-CoV-2) Infection in Children and Adolescents: A Systematic Review. JAMA pediatr 2020.doi:10.101001/jamapediatrics. ,2020.1467.

Parri N, Lenge M, Buonsenso D. Children with Covid-19 in Pediatric Emergency Departments in Italy. 2020.

Riphagen S Gomez X, Gonzalez-Martinez C et al. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet ,23-29 May 2020;395:1607-8. Published online 2020 May 7. doi: 10.1016/S0140-6736(20)31094-1

Siddique H.UK government asked to investigate coronavirus deaths of BAME doctors..Guardian 2020 Apr 10. http://theguardian.comsociety/2020/apr/10/uk-coronavirus-deaths-bame-doctors-bma

Intensive Care National Audit and research Centre.Covid-19 study case mix programme.2020.

Resnick A ,Galea S, Sivashanker K.Covid-19 :the painful price of ignoring health inequalities. BMJ Opinion,18 March 2020.

Toubiana J, Poirault C, Corcia A et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris: prospective observational study. BMJ 2020:369:m2094. bmj.m2094

Verdani L, Mazza A, Gervasoni A et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort Vol 395 June 6, 2020

American Heart Association. Kawasaki


MMWR Morbidity and mortality weekly report. Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020. 2020;69(14):422-6

Nguyen A, David JK, Maden SK et al. Human leucocyte antigen susceptibility map for SARS-CoV-2.J Virol 2020; published online April17.DOI:10.1128/JVI.00510-20

Khunti K, Singh AK , Parek M. Is ethnicity linked to incidence or outcomes of covid-19?BMJ 2020;369:m1548 doi:10.1136/bmj.m1548 (published 20 April 2020).

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2020 Array