Perspective: Poor metabolic health is a major issue for increased COVID-19 mortality in BAME groups
map of obesity worldwide
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Keywords

covid-19
BAME
Metabolic Syndrome
Obesity

How to Cite

Malhotra, A. ., Kamepalli, R. K., & Bamrah, J. (2020). Perspective: Poor metabolic health is a major issue for increased COVID-19 mortality in BAME groups. The Physician, 6(2). https://doi.org/10.38192/1.6.2.4

Abstract

Editorial Note

Type 2 diabetes mellitus and hypertension are the most common comorbidities in patients with coronavirus infections. Emerging evidence demonstrates an important direct metabolic and endocrine mechanistic link to the viral disease process. Metabolic syndrome (METS) is a common denominator to these comorbidities and includes insulin resistance, dyslipidaemia, central obesity and hypertension, which are risk factors for the development of type 2 diabetes and cardiovascular diseases. In 2017, it was estimated that METS affected 20% of the North American population, 25% of the European population and approximately 15% of the Chinese population. In this scenario, the relationship between METS and its comorbidities that aggravate the COVID-19 prognosis cannot be ignored. Also, its presence in different ethnicities and continents places METS as an important risk factor for COVID-19. The authors offer their scientific and epidemiological perspective on this emerging association and urge an international awareness of its devastating consequences among certain populations. This article welcomes debate among scientists, policymakers and wider community leaders. The authors urge clinicians to encourage thorough metabolic control for all patients at risk of COVID-19. (a,b) The Physician welcomes contributions from interested scientists, policymakers and patient representative organisations to continue this discourse.

https://doi.org/10.38192/1.6.2.4
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References

a. Bornstein, S.R., Dalan, R., Hopkins, D. et al. Endocrine and metabolic link to coronavirus infection. Nat Rev Endocrinol 16, 297–298 (2020). https://doi.org/10.1038/s41574-020-0353-9

b. Costa, F.F., Rosário, W.R., Farias, A.C.R., de Souza, R.G., Gondim, R.S.D., Barroso,W.A. Metabolic syndrome and COVID-19: An update on the associated comorbidities and proposed therapies. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2020 14(5), 809-814, https://doi.org/10.1016/j.dsx.2020.06.016

Harrison, E., Docherty, A., Semple, C. (2020) Investigating associations between ethnicity and outcome from COVID-19 UK Gov CO-CIN ePub 25/04/2020 (accessed 7.7.2020) https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/886433/s0238-co-cin-report-ethnicity-outcomes-250420-sage29.pdf

Unnikrishnan, R., Anjana, R.M., Mohan, V. (2014) Diabetes in South Asians: Is the Phenotype Different? Diabetes 63 (1) 53-55; DOI: 10.2337/db13-1592

Chauhan, S., Tamber Aeri, B. (2013) Prevalence of cardiovascular disease in India and its economic impact- A review. Int J Scien Res Publ, 3(10) http://www.ijsrp.org/research-paper-1013/ijsrp-p2234.pdf (accessed 7.7.20)

Andersen CJ, Murphy KE, Fernandez ML. (2016) Impact of Obesity and Metabolic Syndrome on Immunity. Adv Nutr. 7(1):66-75. doi:10.3945/an.115.010207

Arau´ jo, J., Cai, J., Stevens, J. (2019) Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009–2016. Metabolic syndrome and related disorders. 17(1) Mary Ann Liebert, Inc. Pp. 46–52 DOI: 10.1089/met.2018.0105

Kelly, C.T., Mansoor, J., Dohm, G.L., Chapman III, W.H.H., Pender IV, J.R., Pories, W.J. (2014) Hyperinsulinemic syndrome: The metabolic syndrome is broader than you think. Surgery 156 (2); 405-411 https://doi.org/10.1016/j.surg.2014.04.028

Stefan, N., Schick, F., UlrichHaring, H. (2017) Causes, Characteristics, and Consequences of Metabolically Unhealthy Normal Weight in Humans. Cell Metabolism 26 (2) 292-300 https://doi.org/10.1016/j.cmet.2017.07.008

Joshi P, Islam S, Pais P, et al. Risk Factors for Early Myocardial Infarction in South Asians Compared With Individuals in Other Countries. JAMA. 2007;297(3):286–294. doi:10.1001/jama.297.3.286

Dasgupta R, Pillai R, Kumar R, Arora NK. Sugar, salt, fat, and chronic disease epidemic in India: is there need for policy interventions?. Indian J Community Med. 2015;40(2):71-74. doi:10.4103/0970-0218.153858

Iliodromiti S, Ghouri N, Celis-Morales CA, Sattar N, Lumsden MA, Gill JM. Should Physical Activity Recommendations for South Asian Adults Be Ethnicity-Specific? Evidence from a Cross-Sectional Study of South Asian and White European Men and Women. PLoS One. 2016;11(8): doi:10.1371/journal.pone.0160024

Patel, J.V., Chackathayil, J., Hughes, E.A., Webster, C., Lip, G.Y.H., Gill, P.S. (2012) Vitamin D deficiency amongst minority ethnic groups in the UK: a cross sectional study. Int J Cardiol 167 (5) 2172-2176 https://doi.org/10.1016/j.ijcard.2012.05.081

Hu T, Mills KT, Yao L, et al. (2012) Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials. Am J Epidemiol. 176 (Suppl 7):S44-S54 doi:10.1093/aje/kws264

Zhu L, She ZG, Cheng X, et al. (2020) Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab. 31(6):1068-1077.e3. doi:10.1016/j.cmet.2020.04.021

Hyde PN, Sapper TN, Crabtree CD, et al. (2019) Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss. JCI Insight. 4(12): doi:10.1172/jci.insight.128308

Berwick DM. The Moral Determinants of Health. JAMA. Published online June 12, 2020. doi:10.1001/jama.2020.11129

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